Directive Publications

Efficacy and Safety of Exosomes from Whartons Jelly-Derived Mesenchymal Stem Cells in Patients with Spinal Cord Injury Correspondence to Author:  E.C. Savrunlu 1 , S. Kabatas 1,2,3 ,E. Civelek 1,3 ,N. Kaplan 1 , Joel Nguemo Tetio 4 ,Osman Boyali 1 ,M. Bozkurt 5 ,N. Kucukcakir 6 ,Erdal Karaoz  7 .  Eyup Can Savrunlu, Department of Neurosurgery, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, Gaziosmanpasa 34255, Istanbul, Turkey. Serdar Kabatas, Department of Neurosurgery, University of Health Sciences Turkey, Gaziosmanpasa Training and Research Hospital, Gaziosmanpasa 34255, Istanbul, Turkey. Serdar Kabatas, Center for Stem Cell & Gene Therapy Research and Practice, University of Health Sciences Turkey, Gaziosmanpasa 34255, Istanbul, Turkey. Serdar Kabatas, Institude of Health Sciences, Pediatric Allergy-Immunology Programme, Marmara University, Istanbul, Turkey. Erdinc Civelek, Department of Neurosurgery, University of Health Scien...

Evaluation Of The Prevention Of Mother-To-Child Transmission (Pmtct) Of The Human Immunodeficiency Virus (Hiv) In Children Born To Hiv-Positive Mothers In Two Medical Centers In Ouagadougou (Burkina Faso) Correspondence to Author:  Absatou BA/KY1 , Issa Tondé 2 , Thierry Djiguemdé 2 ,Marcel Sawadogo 3 ,Arnaud Dienderé 1 , Idriss Traore 1 ,Yanogo Bibata 2 ,Salimata Diallo 1 , Issoufou Ouédraogo 1 ,, Idrissa Sanou  4 .  1. Bogodogo University Hospital, 2. Charles De Gaulle University Pediatric Hospital, 3. Yalgado Ouedraogo University Hospital, 4. Tengadogo University Hospital DOI:   10.52338/tjocmb.2025.5058 Abstract: Introduction: Mother-to-child transmission is a major route of HIV transmission among children. Despite various prevention programs, Burkina Faso is recording cases of mother-to-child transmission of the human immunodeficiency virus (HIV). This study aims to evaluate measures to prevent mother-to-child transmission at the Kossodo Medical Center with Surg...

Preservation Fluid Cultures In Simultaneous Pancreas And Kidney Transplantation: 20 Years Of Experience . Correspondence to Author:  Lucas M.Garcias 1 , Santiago Reimondez 1 , Maria L.Chamorro 1 , Enzo Giordano 1 , Álvaro Alcaraz 1 , Marcos Marani 1 ,Martín Maraschio 1 .  1 Hepatobiliopancreatic Surgery and Transplant Unit, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina Abstract Simultaneous pancreatic and kidney transplantation (SPK) improves survival and quality of life in patients with type 1 and 2 diabetes mellitus with renal failure. However, postoperative infections remain the main cause of morbidity and mortality, and the role of preservation fluid (PF) as a potential vector for microorganisms is not completely defined. There is limited evidence on the clinical relevance of positive cultures of PF in SPK. Objective:  Evaluate the incidence and clinical relevance of microbial contamination of ...

  Risk And Benefit Assessment Of Hormonal Contraceptive Use In Women With Risk Factors For Cardiovascular Disease: A Systematic Review Correspondence to Author:  Leocadia Felix de Araujo 1 ,Thiago Augusto Rochetti Bezerra  2 .  1. Medical doctor graduated from the Federal University of Fronteira Sul, Passo Fundo Campus, Rio Grande do Sul, Brazil. 2. Medical student. Ribeirão Preto University, Guarujá campus. Doctor of Medical Sciences. University of São Paulo. Ribeirão Preto Medical School, São Paulo, Brazil DOI:   10.52338/jocogr.2025.5084 Abstract: The use of hormonal contraceptives is one of the most effective strategies for reproductive control, but their safety in women with cardiovascular risk factors remains a widely debated topic. This systematic review aimed to evaluate the risks and benefits of hormonal contraceptive use in women with predisposing conditions, such as hypertension, obesity, smoking, thrombophilia, and migraine with aura. Twenty-five stu...

Systematic Review on New Anticoagulants and Their Reversibility, Studies on The Safety, Efficacy, and Antidotes of Direct Oral Anticoagulants (Doacs) Correspondence to Author:  Rosane Rezende De Souza Giuliani 1 , Felipe Santos Teixeira Martiniano 2 ,Nicole Mioto Medeiros 3 ,Lorenzo Francesco Giuliani⁴ 4 , Ana Laura Munerato Zoega Marotti 5 ,Fernanda Tranquillini 6 ,Rafaela Gonçalves Bueno 1 ,Dieudonné Massoma Lembe 6 ,Thiago Augusto Rochetti Bezerra  6,7 , Leocadia Felix De Araujo 8 .  1. Graduated in Medicine Medicine. Head of the Hematology Service at the Portuguese Beneficent Society of Santos, São Paulo, Brazil. Professor of Hematology at the University of Ribeirão Preto (UNAERP), São Paulo, Brazil. 2. Graduated in Medicine. Resident Physician in Internal Medicine, Beneficência Portuguesa Hospital of Santos, São Paulo, Brazil. 3. Graduated in Medicine from the University of Vale do Sapucaí (Univás), Minas Gerais, Brazil. Hematology and Hemotherapy at the Amaral Carva...

Unequal Protection: Rising Infectious Diseases and the Global Vaccine Equity Gap. Correspondence to Author:  Barbara W. K. Son, Ph.D, Wamukota Francis Wambalaba, PhD., AICP.  • Akio Morita School of Business Anaheim University, 1240 South State College Blvd, Anaheim, CA 92806, USA. Email: bson@anaheim.edu. • Development Economics Chandaria School of Business United States International University, Kenya USIU Road Nairobi, Kenya. Email: Fwambalaba1@gmail.com or fwambalaba@usiu.ac.ke DOI:   10.52338/aiv.2025.5048 Abstract: Human exposure to pathogens and the transmission of viruses have been increasing due to a more interconnected world, rising global mobility, growing urban population density, and the effects of climate change. As these trends continue, societies are experiencing more frequent and successive outbreaks of infectious diseases, which pose significant threats to global health, healthcare infrastructure, and both economic and social stabilit...

Removal of a Sapodilla Seed From the Bronchus in an Elderly Patient by Rigid Bronchoscopy at Calmette Hospital, Cambodia Correspondence to Author:  Menghak Heng 1* ,Bunleng Kou 2 ,Chamroeunniron Long 1 , Sarin Chan 1 ,Vanny Sieng 3 ,Pathy Ngeth 3 , Thy Try 4 , Bunpaul Chhar 1,5   1 Pulmonologist, Pulmonology Unit, Medical Ward “A”, Calmette Hospital, Cambodia. 2 Pulmonology Residency, Faculty of Medicine, University of Health Sciences, Cambodia. 3 Anesthegist, Calmette Hospital, Cambodia. 4 Neurosurgeon, Calmette Hospital, Cambodia. 5 Chief of Pulmonology Unit, Medical Ward “A”, Calmette Hospital, Cambodia. DOI:   10.52338/jrmr.2025.5069 Abstract: Introduction:  Foreign body aspiration (FBA) in elderly patients is an uncommon but potentially life-threatening event. Diagnosis is often delayed due to atypical presentations and the absence of radiographic evidence, particularly for radiolucent organic material. Case Presentation:  A 71-year-old woman presented with...

Prevalence of Psychological Disorders in Patients with Fungal Otitis Externa Correspondence to Author:  Hadis Abdollahi Moghaddam 1 , , Abolfazl Zahedi 2 ,Ali Safavi Naeini 2 ,Shahrzad Ghane 3 , Mohammadreza Keramati 4 ,Amirkiarash Kazemi 1 , Neda Pourebrahim 5 ,Mohammad Hossein Hooshangi 3 .  1. Department of Otolaryngology, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2. Department of Otolaryngology, Masih Daneshvari Hospital, Tehran, Iran. 3. Clinical Department, Pharmacy school, Islamic Azad University Tehran Medical Sciences, Tehran, Iran. 4. Clinical Department, Pharmacy School, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 5. Clinical Department, Pharmacy School, Iran University of Medical Sciences, Tehran, Iran. DOI:   10.52338/wjogy.2025.4972 Abstract: Introduction:  Otomycosis is the infectious or non-infectious inflammation of the external auditory canal. Symptoms such as ear ringing and hearing loss ...

Real-World Evidence on a Diosmectite-Based Medical Device: Safety and Efficacy Outcome From Pediatricians and Gastroenterologists. Correspondence to Author:  Miriam Concas 1 , Andrea Mosaico 2 , Sofia Pallante 3 ,Pasquale Pezzella 1 , Gianfranco Trapani 5 ,Gianfranco Trapani 2 ,Stefania Colombo 6 ,Daria Sicari 6 ,Ilaria Carnevali  6 .  1. Pediatrician, Mediocampidano South Sardinia; 2. Gastroenterologist, Azienda Usl Tosaca Nord Ovest; 3. Pediatrician, Rome (RM); 4. Gastroenterologist, Naples (NA); 5. Pediatrician, Nutrition Expert, Sanremo (IM); 6. Scientific Medical Direction PharmaLine s.r.l. Milan (MI), Italy DOI:   10.52338/jotr.2025.5013 Abstract: Background: Diarrhea, both acute and chronic, is a common gastrointestinal condition that significantly affects patients’ quality of life (QoL). Aim of the data collection:  In this investigation, a diosmectite-based medical device (MD), was evaluated as part of Post-Marketing Surveillance (PMS) in compliance wit...

  Biochemical Changes In The Brain Of Malnourished Rats Fed Low Dose Monosodium Glutamate. Correspondence to Author:  Busuyi David Kehinde a , Lamidi Waheed B. Olaniyan b* ,Adebola Olayemi Akintola c Olukemi Lydia Agboola d , Taiwo Margaret Dideolu b , Mayowa Adewusi c , Bala Peter Akwu  e .  a. Department of Chemical Biochemistry, College of Basic Medical Sciences, University of Ilorin, Kwara State, Nigeria. b. Department of Biochemistry, Ladoke Akintola University of Technology, Nigeria. c. Department of Science Laboratory Technology, Ladoke Akintola University of Technology, Nigeria. d. Department of Science Laboratory Technology, College of Agriculture, Science and Technology, Lafia, Nasarawa State, Nigeria. e. Department of Anatomy, Kogi State University, Ayingba, Nigeria. DOI:   10.52338/jotr.2025.4845 Abstract: Monosodium glutamate (MSG) is a non-regulated flavour enhancer with a controversial safety record following lack of intensive and realistic toxici...

Birdshot Chorioretinopathy Treated With Adalimumab And Methotrexate From Onset: The Value Of Regular Angiographic Follow-Up Correspondence to Author:  Maaike Buskermolen¹, MD; Saskia M Rombach², MD, PhD; Mirjam E.J. van Velthoven1 , MD PhD.  1. Uveitis Service, Rotterdam Eye Hospital, Rotterdam, The Netherlands. 2. Department of Internal Medicine, Allergy and Immunology, Erasmus University Medical Centre, Rotterdam, The Netherland DOI:   10.52338/joed.2025.4966 Abstract: Purpose:  Birdshot chorioretinopathy (BSCR) is a chronic, bilateral, auto-immune, posterior uveitis. Through this BSCR case, we investigated the value of angiographic follow-up, after starting immunomodulatory therapy (IMT). Case report:  Upon BSCR diagnosis, a 46-year-old male patient started IMT (adalimumab + methotrexate). At 8 months, we observed clinical quiescence. Angiographically, we observed complete disappearance of the typical choroidal lesions within the first year, but retinal vascu...

Endoscopic Nephrolithotripsy In Children For Renal Calculus (1- 2 Cm): An Observational Study In A Tertiary Care Centre Correspondence to Author:  Sandhani Neog 1 , Debanga Sarma 1 ,Puskal Kumar Bagchi 2 ,Sasanka Kumar Barua 1 , Joël Nguemo Tetio 2 ,Mandeep Phukan 3 ,Nabajeet Das 4 .  Department Of Urology And Renal Transplant Gauhati Medical College And Hospital Guwahati DOI:   10.52338/aou.2025.5005 Abstract: Background: Paediatric nephrolithiasis, although accounting for a small percentage of total stone formers, has been on the rise, particularly among adolescents. Effective and minimally invasive surgical interventions are crucial for achieving high stone-free rates (SFR) while minimizing complications and hospital stay durations in this vulnerable population. Objectives:  This study aimed to evaluate and compare the safety and efficacy of Retrograde Intrarenal Surgery (RIRS) and Mini Percutaneous Nephrolithotomy (mPCNL) in treating renal calculus in children un...

  Leiomyosarcoma Of The Scalp. Correspondence to Author:  Nunzio Di Naro 1 , Marta Meloni 1 , Francesca Ledda 1 , Chiara Floris 1 , Giovanni Antonio Tolu 1,2 .,  1.  Operational Unit of Pathologic Anatomy, Hospital “San Martino”, Oristano, Italy. 2.  Director of the Operational Unit of Pathologic Anatomy, “San Martino” Hospital, Oristano, Italy Abstract: We describe a case of an elderly male subject with a primary diagnosis of leiomyosarcoma of the scalp, whose peculiarity lies in both the rarity of this tumor and its unusual site. Keywords : leiomyosarcoma, scalp, soft tissue tumors. Introduction : Soft tissue sarcomas are a very rare disease, comprising about 1% of malignancies. These are rare, aggressive mesenchymal neoplasms that originate from smooth muscle. The most frequent sites of occurrence are the gastrointestinal tract, retroperitoneum, and in women the uterine site is common. Superficial leiomyosarcomas in particular account for 7-10% of total ...

  Ischemic Stroke in Young Patients: Prevalence and Comorbidities in the 18 to 45 Age Group Correspondence to Author:  Debora González García 1  , Jose Andres Jimenez Sanchez 1  , Enrique Villarreal Ríos 2  , Miguel Ángel González Casas 3  ..  1. Department of Internal Medicine, Hospital General Regional No.1 Querétaro, Instituto Mexicano del Seguro Social. 2. Unit of Epidemiological Research and Health Services, Querétaro, Instituto Mexicano del Seguro Social. 3. Department of Neurology, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Saltillo, Coah. México. DOI:   10.52338/conr.2025.4928 Abstract: Objective:  To determine the prevalence of the 18 to 45 age group among patients who experienced an ischemic cerebrovascular accident (CVA) Methodology:  A descriptive cross-sectional study of patient records who experienced an ischemic cerebrovascular event, confirmed by a simple cranial tomography. The entire uni...

  Histoplasmosis Presenting As Isolated Lymphadenopathy In HIV Positive Patient: A Case Report. Correspondence to Author:  Dinesh Khadka 1 , Sujan Shrestha 2 , Sushil Dhakal 3 , Milan Adhikari 4 , Deepshikha Gaire 5 .  1 Specialist Pathologist, Department of Pathology, Yasmed Medical Center Doha, Qatar. 2 Assistant Professor, National Academy of Medical Sciences (NAMS), Bir Hospital, Nepal. 3 Consultant Pathologist, Maya metro hospital, Dhangadi, Nepal. 4 Assistant Professor, Nepalgunj Medical College Teaching Hospital, Nepalgunj, Nepal. 5 Senior fellow histopathology, East and North Hertfordshire NHS Trust, London, England. DOI:   10.52338/tjocp.2025.4975 Abstract: Histoplasmosis most commonly occurs in immunocompromised patients, primarily affecting lungs. Isolated extra pulmonary manifestations are rare even in Human Immunodeficiency Virus (HIV) positive patients. Case Description:  A known HIV positive, 44 years Male patient presented to Out Patient Departme...

  Enhancing AI-Based Risk Prediction for Animal Disease Outbreaks in Korea Using KAHIS Big Data. Correspondence to Author:  Hachung Yoon, Kyung-Sook Kim, Youngmin Son.  Veterinary Epidemiology Division, Animal and Plant Quarantine Agency, Republic of Korea. DOI:   10.52338/jovsr.2024.4968 Abstract: This study presents an integrated framework for predicting and managing animal disease outbreaks in Korea using artificial intelligence (AI) models powered by big data from the Korea Animal Health Integrated System (KAHIS). First introduced during the 2016–2017 highly pathogenic avian influenza (HPAI) epidemic, these deep learning-based models estimate transmission risk by analyzing livestock vehicle movement patterns. The system produces farm- and municipality-level risk scores to guide targeted interventions for transboundary animal diseases such as HPAI, foot-and-mouth disease (FMD), African swine fever (ASF), and lumpy skin disease (LSD). While the models have proven e...