Directive Publications

Prevalence and Radiological Characteristics of Lumbar Disc Herniation in Adults with Low Back Pain: A Retrospective MRI Study at a Mexican General Hospital. Correspondence to Author:  Claudia Alejandra Martinez Rodriguez MD, Andres Tlacaelel Balderas Chairez MD and Miguel Angel Rivas Garcia MD.  Hospital General: Ciudad Victoria, Durango, Mexico. Email: marro0490@gmail.com (or) anndresb@yahoo.com DOI:   10.52338/tjoa.2025.5276 Abstract: Background:  Lumbar disc herniation (LDH) is a common cause of low back pain (LBP) and disability in adults, often requiring advanced imaging for diagnosis. Although magnetic resonance imaging (MRI) is the gold standard for assessing intervertebral disc pathology, few epidemiological studies have described its prevalence in Mexican populations Objective:  To determine the prevalence and radiological characteristics of lumbar disc herniations in adult patients with LBP undergoing MRI at General Hospital 450, Durango...

  The Role Of Artificial Intelligence In Predicting Obstetric Complications Correspondence to Author:  Juliana Medeiros Lima¹, Maria Victoria de Freitas², Marina Vellasco Oliveira Camelo de Castro³, Mariana Hamer Silva⁴, Catharine Harumi Konno⁵, Ana Lucia de Lima⁶, Vinícius Porto Alves⁷, Ana Karla de Sousa Batista⁸, Leocadia Felix de Araujo⁹, Thiago Augusto Rochetti Bezerra⁹.  ¹ Medical degree from Centro Universitário Lusíada. Medical Residency in Gynecology and Obstetrics at Hospital Municipal de Cubatão, São Paulo. ² Medical degree from Barão de Mauá University Center. Medical residency in Gynecology and Obstetrics at Guilherme Álvaro Hospital, Santos, São Paulo. ³ Medical degree from the University of Rio Verde, Aparecida de Goiânia Campus. Resident in Gynecology and Obstetrics at Guilherme Álvaro Hospital, Santos, São Paulo. ⁴ Medical degree from the Municipal University Center of Franca. Resident in Gynecology and Obstetrics at Guilherme Álvaro Hospital, Santos, São...

Breathing New Life into Conventional Chemotherapy drugs: Enhancing Efficacy via Nanoparticle Codelivery along with Phytochemicals. Correspondence to Author:  Dr. Sharadendu Bali, MBBS, MS, PhD.  Professor, General Surgery, TMC& RC, TMU, Moradabad DOI:   10.52338/tjoco.2025.5260 Abstract: Cancer continues to be one of the leading causes of death worldwide, with 10 million fatalities and 19.3 million new cases reported in 2020. Multidrug resistance (MDR), a formidable issue in chemotherapy, is characterized by the ability of cancer cells to evade cytotoxic drugs through mechanisms such as altered drug targets, disrupted DNA repair, and overexpression of ATP-binding cassette (ABC) transporters like P-glycoprotein (P-gp, responsible for drug efflux). While older oral chemotherapeutics, including 5-fluorouracil (5-FU) and methotrexate, have been effective in certain cancers, their clinical applications are frequently limited by poor bioavailability, dose-limiting toxicitie...

Significances Of Radio-Isotope Imaging Relevant To Management Of Long Bone Sarcomas. Correspondence to Author:  Dr. Promila Verma, Dr. Sharanya A J, Dr. Rhythm.  Department of Conservative Dentistry & Endodontics King George’s Medical University, Lucknow, Uttar Pradesh -226 003. DOI:   10.52338/jodor.2025.5249 Abstract: Background:  Artificial Intelligence (AI) for generative purposes, specifically ChatGPT, has been gradually shaping dental education by supplementing learning, smoothing research, and improving diagnostic insights. Meanwhile, the extent of AI assimilation and knowledge, the benefits perceived, and the ethical concerns among educational stakeholders in dentistry still require thorough review. This study aims to evaluate the perceptions and attitudes of dental practitioners and students toward AI tools in dental education. Methods:  This study employed a structured, pre-validated questionnaire comprising 37 closed- and open-ended questions, adm...

Knowledge And Attitudes Of Non-Nephrologists About Chronic Kidney Disease In N’djamena (Chad) Correspondence to Author:  Ibrahim Hamat  1  , Djibrine Mahamat Djibrine  1  , Haoua Youssouf Said  1  , Charfadine Senoussi  1  , Djibril Youssouf  1  , Nassima Hissein  1  , Yakhoub Hissein  1  , Maimouna Abdelhamid  1  , Mbainodji Dakole Jeremie  1  , Hurbain Houba Dalah  2  , Allamine Adjougoulta  2  , Habiba Affadine  3  , Oumar Abba  3  , Désiré Daboulaye Allahsayim  3 .  1. Nephrology and Hemodialysis Department, National Reference University Hospital, N’Djamena, CHAD 2. Cardiology Department, National Reference University Hospital, N’Djamena, CHAD 3. Endocrinology and Diabetes Department, National Reference University Hospital, N’Djamena, CHAD DOI:   10.52338/tajokd.2025.5257 Abstract: Introduction:  The objective of our study was to ...

Familial Adenomatous Polyposis In A Nigerian Adolescent: A Case Report Of A Rare Hereditary Colonic Disorder Correspondence to Author:  Lukman Olaitan Abdulkareem  1,2 , Abass Ayoola Fawemi  2  , Samuel Kelechi Richard 3 .  1.Department of Internal Medicine, University of Abuja Teaching Hospital Gwagwalada, FCT Abuja, Nigeria. 2.Gastro and Liver Clinic, Arewa Specialist Hospital and Diagnostic Centre, Jabi, FCT Abuja, Nigeria. 3.Department of Histopathology, University of Abuja Teaching Hospital Gwagwalada, FCT Abuja, Nigeria DOI:   10.52338/wjocd.2025.5243 Abstract: Familial Adenomatous Polyposis (FAP) is a rare inherited disorder characterized by early onset of numerous adenomatous polyps in the colon with near certainty of colorectal cancer if untreated. Though it is quite uncommon in the African population, increasing diagnostic access is bringing more cases to clinical attention. We present a case of a 16-year-old Nigerian girl who presented with histo...

Learning Curve and the Influence of Patient Age on Operative Times in Pediatric Robotic Pyeloplasty: A Single-Center Experience Correspondence to Author:  M. Ruiz, L Zelaya, V Vargas, JI Garrido, RM Paredes, A Parente.  Pediatric Surgery Department, Reina Sofia University Hospital. Cordoba, Spain. DOI:   10.52338/airs.2025.5237 Abstract: Objective:  To assess the learning curve and the influence of patient age on operative times in pediatric robotic pyeloplasty, and to determine the safety and effectiveness of the procedure based on our institutional experience. Methods:  A retrospective observational study was conducted including 16 pediatric patients diagnosed with ureteropelvic junction obstruction (PUJO) who underwent robotic-assisted pyeloplasty using the Da Vinci Xi system between 2022 and 2025. Clinical and surgical variables were analyzed, including age, laterality, etiology, docking and closure time (DCT), console time (CT), total operative time (TOT), ...

Aspects of immunopathology in humans during ssRNA virus infections - what do we know and do we have a foundation for treatment? - A narrative review - Part two Correspondence to Author:  Lars Lindberg  1 , Jan Apelqvist  2 .  1. Institution of Clinical Sciences, PICU, Children’s Hospital in Lund, Skane University Hospital, Lund University, Lasarettsgatan 48, S-221 85 Lund, Sweden. 2. Institution of Clinical Sciences, Endocrinology, Skane University Hospital,S-214 28 Malmö, Sweden. DOI:   10.52338/jrmr.2025.5233 Abstract: Background:  The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervous system. Aim:  This narrative revie...

  Aspects of immunopathology in humans during ssRNA virus infections - what do we know and do we have a foundation for treatment? - A narrative review - Part One Correspondence to Author:  Lars Lindberg  1 , Jan Apelqvist  2 .  1. Institution of Clinical Sciences, PICU, Children’s Hospital in Lund, Skane University Hospital, Lund University, Lasarettsgatan 48, S-221 85 Lund, Sweden. 2. Institution of Clinical Sciences, Endocrinology, Skane University Hospital,S-214 28 Malmö, Sweden. DOI:   10.52338/jrmr.2025.5232 Abstract: Background:  The pathophysiological mechanisms underlying single-stranded RNA (ssRNA) virus infections have been investigated extensively and at an accelerated pace in recent years, largely driven by the COVID-19 pandemic. Particular attention has been given to their potential roles in respiratory insufficiency, endothelial dysfunction, thrombosis, and inflammatory responses within the central nervous system. Aim:  This narrativ...

Phylloid Breast Tumor With Osteocondroid Component: A Clinical Case Correspondence to Author:  Nunzio Di Naro  1  , Marta Meloni  1  , Francesca Ledda  1  , Chiara Floris  1  , Eleonora Noto  1  , Giovanni Antonio Tolu  1,2 .  1. Pathological Anatomy Unit, San Martino Hospital, Oristano, Italy. 2. Director of the Pathological Anatomy Unit, San Martino Hospital, Oristano, Italy DOI:   10.52338/tjoco.2025.5221 Abstract: Malignant phyllodes tumors account for 0.18% of all malignant breast tumors, and of these, tumors with heterologous differentiation of osteosarcoma and chondrosarcoma are rare, accounting for 1.3% of all phyllodes tumors. We report a case of malignant phylloid tumor with atypical heterologous osteochondroid component, which arrived at our Pathological Anatomy Unit Keywords:  Osteochondroid differentiation, malignant phylloid, breast cancer, thoracic oncology. Citation: Dr.Marta Meloni, Philloid Brea...

  Right Ventricle Myocardial Abscess Developed After Penetrating Cardiac Injury Correspondence to Author:  Andrea Ardigò MD, Salvatore Poddi MD, Alessio Rungatscher MD PhD.  Division of Cardiac Surgery, University of Verona Medical Center, Verona, Italy DOI:   10.52338/jocd.2025.5250 Abstract: Myocardial abscess is a life-threatening condition characterized by a suppurative infection of the myocardium. It typically arises as a complication of infective endocarditis or, less frequently, other conditions such as sepsis or myocardial infarction. The most common localizations are the left ventricular wall and the interventricular septum. Isolated myocardial abscesses are exceedingly rare. In this report, we present the case of a 43-year-old woman who presented with a right ventricle myocardial abscess 6 months after surgical repair of a penetrating cardiac injury. To our knowledge, this is the first reported case of isolated right ventricle myocardial abscess after penet...

Early Detection Of Renal Injury In Elderly Patients With Chronic Obstructive Pulmonary Disease. Correspondence to Author:  Shimaa Nour Morsi 1* , Ahmed Tawfeek 2 , Ahmed Nagah Noureldin 3 , Eptehal M. Dongol 4 , and Doaa Gadallah 1 .  1 Department of Chest diseases, Faculty of Medicine, Sohag University, Egypt. 2 Department of Clinical and chemical pathology, Faculty of Medicine, Sohag University, Egypt. 3 Department of internal medicine, Faculty of Medicine, Sohag University, Egypt. 4 Department of Chest diseases, Qena Faculty of Medicine, South Valley University, Egypt. DOI:   10.52338/jrmr.2025.5218 Abstract: Background:  One prevalent complication of COPD is renal damage. Our objective is to examine the function of cystatin C and β2 microglobulin as indicators for detecting early kidney damage among older individuals with stable COPD and during exacerbations. Methods:  Prospective comparative cross-sectional study recruited 135 COPD cases, classified as 86 C...

Inositol And High-Dose Water-Soluble Vitamins Supplementation To Improve Psychological WellBeing, Cognitive Function, Perceived Stress, Physical Fatigue, And Sleep Quality. Correspondence to Author:  Giuseppina Garbelli 1 , Federico Maffezzoni 2 , Serena Miglio 2 , Patrizia Giordano 3 , Stefano Agostini 4 .  1.Vigoni della Somaglia Foundation, Somaglia (LO), Italy 2.Clinical Psychology, Oberdan Outpatient Clinic, Brescia (BS), Italy 3.Scientific Researcher, Lodi (LO), Italy 4.MèDISIN S.r.l., Lissone (MB), Italy DOI:   10.52338/jonafsr.2025.5214 Abstract: The general population commonly utilizes nutritional supplementation with one or more water-soluble vitamins to reduce perceived stress and fatigue, improve physical and mental performance, as well as sleep quality. However, to date, no published studies have evaluated the daily use of a nutraceutical formulation combining inositol with high doses of all water-soluble vitamins, aimed at reducing emotional distress, physic...

Current Status and Future Perspectives of Cancer Rehabilitation in Palliative Care: A Systematic– Narrative Hybrid Review. Correspondence to Author:   Shuhei Ohkura  a , Satoru Sagae  b,* , Nayu Someki  c , Ayumi Tanimoto  d , Arisa Konishi  d , Ayako Iizuka  e , Aiki Takedae,Mikiko Ogasawara  f , Riyo Shinya  g , Yoshihito Ohhara  h .,  a Department of Rehabilitation Oncology, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. b Department of Internal Medicine, Palliative Care, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. c Department of Nursing Section of Outpatient Chemotherapy, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. d Department of Pharmacy, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. e Department of Nursing 6 East Ward, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. f Department of Nutrition, Sapporo Kojinkai Memorial Hospital, Sapporo, Japan. g Department of Medical Coordination, Sapporo Kojin...

  Development Of Virtual Reality-Based Therapy Protocols For Cardiovascular Rehabilitation. Correspondence to Author:  Brenda Maria Oliveira Gomes da Costa 1  , Mayara Moura Alves da Cruz 2  , Marianne Penachini da Costa de Rezende Barbosa 1  ..  1. Fundação Educacional do Município de Assis (FEMA), Assis, São Paulo, Brasil. 2. Universidade Estadual Paulista, Júlio de Mesquita Filho (FCT-UNESP) of Presidente Prudente - São Paulo DOI:   10.52338/jocd.2025.5198 Abstract: Due to its playful nature, virtual reality protocols (VR) is able to increase adherence in patients taking part in both for the treatment and prevention of cardiovascular diseases (CVD) and cardiovascular rehabilitation (CR). Despite all the positive and significant results proven by the aforementioned studies, the games used were commercial exergames, they were created for healthy people, and not intended to be used in cardiovascular rehabilitation (CR). Other several crucial aspects an...

  Use of Bempedoic Acid in an Out-Patient Setting: an Assessment of Efficacy Heterogeneity. Correspondence to Author:  Amro Maarouf 1  , Manjit K Shergill 1  , Alan F Jones 1  , John Marriott 2  , Sudarshan Ramachandran 1 .  1. Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, West Midlands, United Kingdom. 2. Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom. DOI:   10.52338/jocd.2025.5198 Abstract: Objectives:  We describe decreases in total cholesterol (TC), non-high density lipoprotein-cholesterol (non-HDL-C) and low density lipoproteincholesterol (LDL-C) following bempedoic acid treatment in an out-patient setting and compare the results to those observed in phase 3 efficacy trials. Design:  We analysed a cohort of 113 patients not achieving LDL-C targets commenced on bempedoic acid after previous treatment with statins and ezetimibe using an intention-to-tr...

  The Role Of Utilizing Community Oncology Care To Decrease Cancer-Related Financial Toxicity Correspondence to Author:  Lucio Gordan MD 1  , H. H. Nivita Singh-Bulkan PA-C MS, Amanda Warner MS BSN 1  . Joshua Eaves BA 1  , David Wenk MD 1  , Matthew Fink MD 1  , Ryan Ciarrocchi 1 .  President / Managing Physician Chair of Executive Board Florida Cancer Specialists & Research Institute. Director, Real-World Evidence Florida Cancer Specialists & Research Institute. Florida Cancer Specialists & Research Institute. DOI:   10.52338/tajoph.2025.5171 PURPOSE: The cost of cancer care in the United States remains a significant concern, particularly considering the rising expenditures associated with oncology services1. Cancer related financial toxicity - the economic burden of cancer care to patients and their families - has increasingly become a critical factor when evaluating quality-of-care. A notable area of distinction between commun...