Directive Publications

Carboplatin versus cisplatin: an observational study in locally advanced cervical cancera . Correspondence to Author:  Iris Otoya Fernández Instituto Nacional de Enfermedades Neoplásicas, Av. Angamos Este 2520. Surquillo, Lima, Peru. DOI : 10.52338/wjoncgy.2024.3977 Abstract: Background : Cisplatin-based chemoradiation is the standard treatment for locally advanced cervical cancer. However, the toxicity and prolonged infusion time associated with cisplatin urges the search for options that yield similar outcomes. Our objective is to compare the effectiveness of carboplatin versus cisplatin. Methods : The current study is observational and retrospective, consisting of 183 patients with locally advanced cervical cancer who underwent chemoradiation treatment at the National Institute of Neoplastic Diseases, Lima, Peru, between 2014 and 2015. We analyzed their adverse events, response to therapy, disease evolution, and survival outcomes. Results : The squamous cell carcinoma subty...

Characteristics and survival associated with pathological complete response following neoadjuvant treatmentof locally advanced gastric cancer: a multicenter analysis in a real-world setting. Correspondence to Author:   Miao-Zhen Qiu ,  Department of Medical Oncology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou 510060, China. DOI:  10.52338/immunology.2024.3977 Abstract: Background : Neoadjuvant treatment (NAT) has become the standard treatment for locally advanced gastric cancer (LAGC). A small number of patients could achieve pathological complete response (pCR) after NAT. This study was performed to determine the factors predicting pCR and recurrence, and to investigate the pattern of recurrence in patients with pCR after NAT followed by surgery. Methods : We collected 488 LAGC patients who underwent surgery in three hospitals between Septemb...

POST-COVID SYNDROME - A MODEL OF PATHOGENESIS . Correspondence to Author:  Alexander Kazimirskii Pirogov Russian National Research Medical University, Ostrovityanova St.1, Moscow 117997, Russian Federation. DOI:  10.52338/immunology.2024.3957 Abstract: Post- COVID is characterized by a decrease in the patients’ quality of life, a tendency to hemocoagulation. Symptoms of post- COVID are diverse and difficult to classify. Purpose : Study of neutrophil extracellular traps (NETs) in post-COVID patients to clarify the mechanisms of damage. Patients and methods : Two groups of patients with post COVID were examined. In the first group (21 patients), COVID-19 treatment was carried out in a hospital, in the second group (20 patients) - on an outpatient clinic. The comparison group consisted of 10 patients with acute appendicitis, the control group consisted of 20 healthy people. Neutrophils were isolated using gradient centrifugation. NETs was visualized using fluorescence microscopy ...

Hyalinosis : A preliminary communication regardingvery interesting and provocative clinical observations. Correspondence to Author:   Gernot P. Tilz  The Vascular Diseases of the Brain and the Heart May Have a Different Etiology. DOI:  10.52338/immunology.2024.3958 Abstract: This is a brief comment on 55 years of clinical experience and some autopsy observations with the late pathologist Prof Hans Becker.. It is now recognized that vascular disease of the brain and coronary vessels may be of two different entities. We encounter patients with advanced disease of coronary and peripheral arteries with no perceptible evidence of “cerebral arteriosclerosis” and conversely people with advanced dementia of vascular origin despite unaffected coronary and peripheral arteries. Some observations at autopsies concerning this matter have come to the conclusion that in general coronary heart disease is mainly sclerotic and inflammatory with all the well - known risk factors of which we...

Contrast Media and Contrast Agents in Radiology Correspondence to Author:  Siniša Franjić Independent Researcher. DOI:   10.52338/aor.2024.3950 Abstract: Contrast agents are substances that absorb X-rays from tissues and organs. Displaying organs and organ systems with the use of contrast agents is called a contrast diagnostic method. This method is used to visualize even the smallest possible differences in the structure of tissues, organs and pathological processes. They are used for image display methods in: radiography, diascopy, computerized tomography, magnetic resonance, ultrasound diagnostics, etc. Any administration of contrast media containing iodine atoms can cause a series of adverse reactions in the patient. Keywords Contrast Media, Contrast Agents, ICM, CT, PET - CT, Health. Citation: Siniša Franjić. Contrast Media and Contrast Agents in Radiology. Annals of Radiology 2024.

Missed Foreign Body Falsely Interpreted as Glass in Surgery Correspondence to Author:  Jakob Hama Internal Medicine, New York City Health and Hospitals Queens Hospital Center, 82-68 164th St, Queens, NY. DOI:  10.52338/aor.2024.3927 Abstract: Retained foreign bodies (FBs) in soft tissues are typically a complication of open wounds from trauma, accidents, and surgery, for which plenty of patients seek acute medical care. The importance of localizing these FBs is vital to patient health because it reduces the detrimental complications of loss of function, local tissue damage, infection, and sepsis. In today’s modern age, many automobile taillights are composed of three components: the polycarbonate outer shell, the light bulb, and various metal casings. Occasionally, patients present with one of these objects retained in their body. Here, we present the case of a FB that was dictated as a hematoma; however, it was a piece of polycarbonate that was reported as a piece of glass in...

An unusual cause of adult transverse colonic intussusception with obstruction: Multiple large submucosal lipomas in a 50-year-old male . Correspondence to Author:  Zachary I. Merhavy Ross University School of Medicine, Bridgetown, Barbados. DOI:  10.52338/wjsurgy.2024.1026 Abstract: Introduction: TIntussusception is a gastrointestinal condition that predominantly affects the pediatric population. Although uncommon, it can occur in adults and is typically due to a pathological lead point that causes telescoping of the intestine during peristalsis. In this case, a 50-year-old male presents with abdominal pain, distension, diarrhea, and unintentional weight loss, which was revealed to be caused by intussusception that originated at a cluster of submucosal lipomas in the transverse colon. This patient had recently immigrated to the U.S. from Africa, and had missed his colorectal screening, which is recommended at age 45 for every person. It is crucial to accurately screen for, dia...

Comprehensive versus Less-than-Comprehensive Fields in the Radiotherapeutic Managementof Unknown Primary Cancer of the Head andNeck . Correspondence to Author:  Allen M. Chen, M.D. Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS. DOI:  10.52338/cicr.2024.3996 Abstract: Purpose  To compare clinical outcomes among patients treated with comprehensive and non-comprehensive radiation fields for squamous cell carcinoma of occult primary origin involving the cervical lymph nodes. Methods and Materials  From January 2014 to April 2018, a total of 33 patients at a single institution were treated by intensity-modulated radiation therapy for squamous cell carcinoma metastatic to the cervical lymph nodes of occult primary origin. Seventeen patients (52%) were treated by primary radiation; 16 (48%) were treated after neck surgery. N-classification was N1 (3 patients); N2a (8 patients); N2b (15 patients); N2c (2 patients); and N3 (5 patients)....

  A highly antioxidant functional apple-based juice fortified with aqueous extract of freeze-dried Moringa oleifera leaves: study of physicochemical, nutritional and sensory properties Correspondence to Author:   Sahar Dandachy Department of Nutrition, Faculty of Public Health, Lebanese University, Tripoli 1300, Lebanon. DOI :  10.52338/jonafsr.2024.3952 Abstract: Developing foods with boosted functionality to minimize the potential side effects of oxidative/nitrosative stress and support the immune system while responding to consumers’ needs and preferences is a challenging trend in the food industry. The use of Moringa oleifera leaves, characterized by their high nutritional value and multiple pharmacological properties, is emerging in food applications. The present study aimed at developing a functional ready-to-serve apple based juice fortified with an aqueous extract of freeze-dried Moringa oleifera leaves (A.F.D.MO), studying the antioxidant, physicochemical, and nu...

Demystifying Barriers to and Drivers of Exclusive Breastfeeding Practice – A Cross-Sectional Study Among Mothers & Caregivers of Children Under 5 in Kaduna State, Nigeria.  Correspondence to Author:   Chinedu Onyezobi Project implementation Unit, Kaduna State Ministry of Health.   DOI:  10.52338/jonafsr.2024.3935 Abstract: This study presents findings from a cross-sectional survey conducted among mothers and caregivers of children under 5 in Kaduna State, Nigeria. Out of the 1647 collected questionnaires, 77.5% were validated for analysis. Results reveal that 53.3% of the women were aged 20-29 years, with older adolescent mothers (18-19 years) comprising 7.8%. The majority were married (97.8%), and over two-thirds had at least primary education (69.5%). While 54.5% identified as housewives, 28.7% engaged in petty trading, and 12.3% pursued farming full-time. Table 2 in the appendix indicates good knowledge of exclusive breastfeeding (EBF) practices, with 88.4% kn...

An unusual cause of adult transverse colonic intussusception with obstruction: Multiple large submucosal lipomas in a 50-year-old male Authors: Zachary I. Merhavy Ross University School of Medicine, Bridgetown, Barbados Correspondence to Author:  Zachary I. Merhavy DOI:  10.52338/wjsurgy.2024.1026 Abstract: Introduction: TIntussusception is a gastrointestinal condition that predominantly affects the pediatric population. Although uncommon, it can occur in adults and is typically due to a pathological lead point that causes telescoping of the intestine during peristalsis. In this case, a 50-year-old male presents with abdominal pain, distension, diarrhea, and unintentional weight loss, which was revealed to be caused by intussusception that originated at a cluster of submucosal lipomas in the transverse colon. This patient had recently immigrated to the U.S. from Africa, and had missed his colorectal screening, which is recommended at age 45 for every person. It is crucial to a...

Comprehensive versus Less-than-Comprehensive Fields in the Radiotherapeutic Management of Unknown Primary Cancer of the Head and Neck. Authors: *#Ryan Morse, M.D., *Rohit G. Ganju, M.D.,*фAllen M. Chen, M.D. *Department of Radiation Oncology, University of Kansas Cancer Center, Kansas City, KS. #Department of Radiation Oncology, University of North Carolina Health, Chapel Hill, NC. фDepartment of Radiation Oncology, University of California, Irvine, Health, Orange, CA. Correspondence to Author:  Allen M. Chen, M.D. DOI:  10.52338/cicr.2024.3996 Abstract: Purpose  To compare clinical outcomes among patients treated with comprehensive and non-comprehensive radiation fields for squamous cell carcinoma of occult primary origin involving the cervical lymph nodes. Methods and Materials  From January 2014 to April 2018, a total of 33 patients at a single institution were treated by intensity-modulated radiation therapy for squamous cell carcinoma metastatic to the cervical ...

A highly antioxidant functional apple based juice fortified with aqueous extract of freeze-dried Moringa oleifera leaves: study of physicochemical, nutritional and sensory properties Correspondence to Author:   Sahar Dandachy,  Department of Nutrition, Faculty of Public Health, Lebanese University, Tripoli 1300, Lebanon DOI:  10.52338/jonafsr.2024.3952 Abstract: Developing foods with boosted functionality to minimize the potential side effects of oxidative/nitrosative stress and support the immune system while responding to consumers’ needs and preferences is a challenging trend in the food industry. The use of Moringa oleifera leaves, characterized by their high nutritional value and multiple pharmacological properties, is emerging in food applications. The present study aimed at developing a functional ready-to-serve apple based juice fortified with an aqueous extract of freeze-dried Moringa oleifera leaves (A.F.D.MO), studying the antioxidant, physicochemical, and nutr...

Demystifying Barriers to and Drivers of Exclusive Breastfeeding Practice – A Cross-Sectional Study Among Mothers & Caregivers of Children Under 5 in Kaduna State, Nigeria. Correspondence to Author:   Chinedu Onyezobi,  Project implementation Unit, Kaduna State Ministry of Health. DOI:  10.52338/jonafsr.2024.3935 Abstract: This study presents findings from a cross-sectional survey conducted among mothers and caregivers of children under 5 in Kaduna State, Nigeria. Out of the 1647 collected questionnaires, 77.5% were validated for analysis. Results reveal that 53.3% of the women were aged 20-29 years, with older adolescent mothers (18-19 years) comprising 7.8%. The majority were married (97.8%), and over two-thirds had at least primary education (69.5%). While 54.5% identified as housewives, 28.7% engaged in petty trading, and 12.3% pursued farming full-time. Table 2 in the appendix indicates good knowledge of exclusive breastfeeding (EBF) practices, with 88.4% knowing ...

Use of the International Prostate Symptom Score in men with Multiple Sclerosis . Correspondence to Author:  Bilal Chughtaia,  Bilal Chughtai ; Department of Urology, New York Presbyterian Hospital, New York, NY. DOI:  10.52338/aou.2024.3925 Abstract: Objective : Men with multiple sclerosis (MS) tend to present with urinary symptoms potentially translating to significant findings on urodynamics (UDS). We sought to assess the reliability and prognostic value of the International Prostate Symptom Score (IPSS) and Quality of Life (QoL) in patients with MS. Methods : A prospective study between July 2014 and August 2016 included 40 consecutive men with MS and lower urinary tract symptoms (LUTs) referred for video UDS. All participants completed the IPSS and QoL assessments. Results were compared and correlated to UDS parameters. Results : Mean (±SD) age, IPSS, and QoL were 53.7 ± 13.5 years, 16.7 ± 8.9 and 4.1 ± 1.4, respectively. The most common presenting symptom and UDS fin...

  Improving Peritoneal Dialysis Effluent Sample CollectionTechniquestoLowerCulture-Negative Peritonitis Rate: A Single-Center Experience . Correspondence to Author:   Subodh J. Saggi. Department of Medicine, Division of Nephrology, State University of New York Downstate Health Sciences University, Brooklyn, NY 11203, USA. DOI:  10.52338/tjon.2024.3948 Abstract: Background :  Peritonitis remains the most feared complication of End Stage Renal Disease (ESRD) patients on peritoneal dialysis (PD), but cultures are often negative. Our study was aimed to determine if improving the collection techniques of peritoneal fluid would reduce the rates of Culture Negative Peritonitis (CNP) as recommended in the 2020 ISPD guidelines. Methods :  We implemented a policy to standardize the collection techniques of PD effluent by introducing an additional step thatincreased the concentration of organisms in the PD effluent. This additional step consisted of culturing resuspended p...

  Effect of composite resin monomer BisGMA on odontogenic differentiation of human dental pulp stem cells Correspondence to Author:  Gong yu,  Department of Endodontics,Affiliated Stomatological Hospital of Kunming Medical University,650031 Kunming, China. DOI:  10.52338/jodor.2024.3916 Abstract: Objective : To study the effect of composite resin monomer BisGMA on human dental pulp stem cell (hDPSCs) odontoblasts differentiation, and explore the effect of composite resin filling teeth on dentin formation. Material and Methods : separate and culture hDPSCs, identify cell phenotype by flow cytometry, and induce staining to assess multidirectional differentiation potential. The hDPSCs was stimulated with different concentrations of monomeric BisGMA, and the odontoblast differentiation capacity of each group was determined by CCK-8 assay, alkaline phosphatase activity detection, and q-PCR. Results: CCK-8 showed that the addition of 0.5 mM —— 8 mM BisGMA affected the cell...