Directive Publications

A Review of Major Skin Cancers: Physiology, Diseases, Market Analysis, and Treatments. Correspondence to Author:  Sophia Welsh, Tawil Bill.  Department of Bioengineering, University of California, Los Angeles (UCLA), USA DOI:   10.52338/jocd.2025.4959 Abstract: Skin cancer is one of the most common cancer types, affecting approximately 20 percent of Americans throughout their lifetime. There are a multitude of types but the majority of skin cancer cases are one of three types: Melanoma, Basal cell carcinoma, and Squamous cell carcinoma. Like most cancers, early detection for skin cancer and access to proper treatments are keys to increasing survival rates. Constant interest in increasing survival rates have led to the combined skin cancer diagnostics and treatment market to have grown to 19.83 billion USD market size as of 2023. The diagnostics are visually based and encompass both a doctor assessment and an additional biopsy for closer identification. The variety of trea...

  Diabetes Screening as a Preventive Strategy: The Role of POCT and Telemedicine Correspondence to Author:  Domenico Tripodi 1,3 , Paola Cosentino 1,2 , Davide Sacco 4,5 , Valerio Leoni 1,2  and Roberto Dominici 1 .  1. Laboratory of Clinical Pathology and Toxicology, Hospital Pio XI of Desio, ASST-Brianza, Italy. 2. Department of Medicine and Surgery, University of Milan Bicocca, Italy. 3. Department of Science and Technology (DST), University of Sannio, 82100 Benevento, Italy. 4. Department of Brain and Behavioral Sciences, University of Pavia, 27100 Pavia, Italy. 5. Department of Molecular Genetics and Cytogenetics, Centro Diagnostico Italiano, 20147 Milan, Italy. DOI:   10.52338/jodr.2025.4865 Abstract: Diabetes is a chronic metabolic disorder of growing global concern. By 2030, it is projected to affect 643 million individuals worldwide. Early identification and management are essential to prevent complications and reduce healthcare costs. This study invest...

Temporal Dynamics Of Cocoa Growing In Mocajuba, Eastern Amazonia: Environmental And Socioeconomic Implications. Correspondence to Author:  Daniel Fernandes Rodrigues Barroso 1* , José Francisco Berrêdo 2 , Marcia Aparecida da Silva Pimentel 3 , Marcelo Cordeiro Thalês 2 ; Maria do Perpétuo Socorro Progene Vilhena 4 .  1 Department of Education, Federal Institute of Maranhão, Campus Itapecuru Mirim, Itapecuru Mirim, MA, Brazil, E-mail: daniel.rodrigues@ifma.edu.br. 2 Coordination of Earth Sciences and Ecology, Emílio Goeldi Museum of Pará. 3 Institute of Philosophy and Human Sciences, Federal University of Pará. 4 Federal Rural University of Amazonia. DOI:   10.52338/joes.2025.4934 Abstract: Brazil is the world’s seventh largest cocoa producer. This study analyzes the dynamics and socio-economic and environmental relevance of cocoa farming in Mocajuba, using time series and econometric models. Vector error correction (VEC) and autoregressive (VAR) models were applied to as...

Factors Associated with Hydroelectrolytic Disorders in Chronic Kidney Disease in Departmental Teaching Hospital Borgou/Alibori (Benin). Correspondence to Author:  Séraphin Ahoui 1* , Julien Attinon 2 , Blaise Adelin Tchaou 2 , Aimé Vinasse 1 , Ingrid A. Makam Fokam 1 , JosephGodonou 1 , Aubin M Melikan 1 , Jacques Vigan 3 .  1 Department of Nephrology, University and Departmental Hospital Center Borgou, BP 02 Parakou Benin, 2 Department of Anesthesia-Resuscitation and Emergency, University and Departmental Hospital Center Borgou, Alibori, Parakou, Benin 3 University nephrology and haemodialysis Clinic, National University Hospital of Cotonou Hubert K. Maga Benin. DOI:   10.52338/tjon.2025.4941 Abstract Introduction:  Chronic kidney disease (CKD) represents a real public health problem on a continental and global scale. The existence of hydroelectrolyte disorders in a patient suffering from CKD would constitute a risk factor for the progression of this condition. Obje...

  Anti-Mitotic Properties Of Efavirenz On Cal 27 Cell Line Correspondence to Author:  Olatunji BI (MD) I  , Olaleye OO (PHD) II , McNeil RTO (PHD) III .  I * Department of Anatomy and Histology, Sefako Makgatho Health Science University, Ga-Rankuwa . Phone: 061 966 7054, Email: giftandjoy01@gmail. com. 11* Dept of Oral Biological Sciences, Faculty of Health sciences,University of the Witwatersrand Medical School, Johannesburg South Africa. Phone: 078 742 2147 Email: Olatunbosun.Olaleye@wits.ac.za 111* Department of Human Anatomy, Faculty of Basic Medical sciences, College of Medicine, University of Jos Nigeria. Phone: 071 975 9167. Email: rosiemcneil@gmail.com DOI:   10.52338/joctr.2025.4896 Abstract: Introduction:  Some studies have suggested that Efavirenz may have anti-proliferative effects on various cancer cell lines, potentially through mechanisms that involve cell cycle arrest and inhibition of cell division. The aim of this work is to investigate th...

The Impact Of Sleep On Heart Rate Variability And Cardiovascular Risk: An Integrative Review Of Sleep Medicine And Cardiology. Correspondence to Author:  Rafaela Gonçalves Bueno 1 , Thiago Augusto Rochetti Bezerra  1,2 .  1. Medical student. University of Ribeirão Preto (UNAERP). Guarujá, São Paulo Brazil. 2. PhD in Medical Sciences. Ribeirão Preto Medical School. University of São Paulo (FMRP/ USP). Ribeirão Preto, São Paulo, Brazil. DOI:   10.52338/jocd.2025.4936 Abstract: Introduction:  Sleep plays a fundamental role in cardiovascular autonomic regulation. Heart rate variability (HRV) is a sensitive indicator of this balance and can be negatively influenced by sleep disorders. Objective:  To investigate, through a systematic review, the relationship between sleep disorders, HRV and cardiovascular risk. Methods:  Systematic review conducted according to PRISMA 2020 in six databases. 42 studies published between 2013 and 2024 that correlated sleep, HR...

Booster with Intranasal Vaccine Candidate Mambisa Activates the Expression of Tissue Resident Memory T Cell Markers. Correspondence to Author:  Daniel Palenzuela Gardón 1  ,Diogenes Quintana Vazquez 1 , Hamlet Camacho Rodriguez 1 , Dania Vazque Blomquist 1 Jorge Aguiar Santiago 1 ,Heryslina Izquierdo Reinoso 1 , Chabeli Rodriguez Ibarra 1 , Maité Delgado Espina 1 , Anabel Alvarez Acosta 1 ,Alberto Cintado Benitez 1 , Karen Cobas Acosta 1 , Iris Valdez Prado 1 , Gilda Lemos Pérez 1 , Isela María García Tamayo 1 , Ingrid Rodriguez Alonso 1 , Julio Cesar Aguilar 1 , Damian Mainet Gonzalez 1 , Amanda Visal Fernandez 1 , Rubén Amaya Izquierdo 1 ,Diosladia Urquiza Noa 1 , Pedro Puente Pérez 1 , Gerardo Guillen Nieto 1 .  1. Center for Genetic Engineering and Biotechnology, Havana, Cuba. DOI:   10.52338/joid.2025.4900 Abstract: The study evaluates the efficacy of the nasal booster vaccine candidate Mambisa in the activation of tissue-resident memory T cells (TRM), that are ...

  Assessment Of Quality And Safety Of Baby Body Lotions Sold In The Town Of Dschang In Cameroon. Correspondence to Author:  Jocelyne Fabiola Kuete 1 , Guy Sedar Singor Njateng 1,2*   1 Department of Biochemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, Cameroon. 2  Department of Pharmaceutical sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, P.O. Box 95 Dschang, Cameroon DOI:   10.52338/accm.2025.4884 Abstract: Context:  Constantly evolving regulations are forcing the cosmetics industry to keep a close eye on the latest developments, especially as there have been many controversies about the poor quality and undesirable effects of cosmetic products. When applying these products to the skin, it is important to distinguish between products that can be rinsed off easily and those that cannot be rinsed off in the case of products intended for children under the age of 3, given the fragility of their skin....

Platelet Indexes and Disease Activity in Juvenile Idiopathic Arthritis Correspondence to Author:  Maria Mercedes Picarelli , Henrique Luiz Staub, Luiz Carlos Bodanese   • Rheumatology Department – São Lucas Hospital - Pontifical Catholic University do Rio Grande do Sul. Porto Alegre - Rio Grande do Sul – Brazil. Email: maria.picarelli@pucrs.br • Rheumatology Department – São Lucas Hospital - Pontifical Catholic University do Rio Grande do Sul.Email: henriquestaub@terra.com.br • Cardiology Department - Hospital São Lucas - Pontifical University Católica do Rio Grande do Sul.Porto Alegre - Rio Grande do Sul – Brazil. Email: lcbodanese@pucrs.br DOI:   10.52338/jocp.2025.4855 Abstract: Objective:  To test correlation between mean platelet volume (MPV), immature platelet fraction (IPF) with disease activity in a group of juvenile idiopathic arthritis (JIA) patients defined by JADAS 71. Determinate sensitivity, specificity, positive and negative predictive value. Methods: ...

Chemotherapy Approaches in the Treatment of Childhood Retinoblastoma: Comparison of Intravenous, Intra-arterial and Intravitreal Therapies. Correspondence to Author:  Gabriel Queiroz Sabbag 1 , Marcus Baia Fonseca 2 ,Isabella Pereira Lério 2 , Rafaela Gonçalves Bueno 3 , Bárbara Leitão 3 , Isabela Marini Ferreira 4 , Giovana Casarini Yamashiro 4 , Bruno Fiorio Pinheiro 5 ,; Marcos Brizola 2 , Mariana Machado Regonha 2 , Aghata Cruz Abreu 2 , Gabriel Leonardo Saraiva 2 , Jenyffer Victoria Cabrera Villca  2 , Adriana F. Viana  2 , Thiago Augusto Rochetti Bezerra 2-6 , Rubens Rodrigues Tudela 7 , Joel Eloi Belo Junior 8 , Hamilton Roberto M.de Oliveira Carriço 10 , Délio Tiago Martins Malaquias 2-9 .  1. Medical degree from São Leopoldo Mandic Araras, São Paulo. Resident in Ophthalmology 2. Medical student. Ribeirão Preto University (UNAERP), Guarujá. São Paulo, Brazil. 3. Medical student. Professor Franco Montoro Municipal College. Mogi Guaçu, São Paulo. 4. Medical stu...

  Sleep Deprivation, Sleep-Wake Disorders and Mental Health in Medical Students: A Systematic Review. Correspondence to Author:  Gabriela de Luna Costa Pinheiro 1 , Thais Pinheiro Meira Barbosa 8 ,Rafaela Gonçalves Bueno 6 , Larissa Caetano Faleiro 2 , Julienne Fernanda Carvalho e Silva 3 , Jaqueline de Carvalho Ferreira 4 , Isabela Marini Ferreira 4 , Giovana Casarini Yamashiro 4 , Beatriz Randone Pereira 4 , ; Rubens Rodrigues Tudela 5 , Diego Paulino Mariz 6 , Délio Tiago Martins Malaquias 6 , Aline Cristina Couto da Silva 6 , Rafaella Rodrigues Neves 6 , Bruna Felix de Lima Souza Ramos 6 , Maria Heloisa Martins Gimenes Gomes 6 , Adriana F. Viana 6 , Thiago Augusto Rochetti Bezerra 6,7 .  1. Medical degree from the Universidade Municipal de São Caetano do Sul (USCS) / Post- graduate degree in Psychiatry from the Hospital Israelita Albert Einstein. 2. Medical student. Zarn College. Itumbiara, Goiás, Brazil. 3. Medical student. University of the Integration of the Americ...

Acceptability And Validation By Use Of A Location Device To Promote Resident Autonomy In Residential Facility For Dependent Elderly People. Correspondence to Author:  Raksmey Phan, Nel Samama  1. Mines Saint-Etienne, Université Clermont Auvergne, INP Clermont Auvergne, CNRS, UMR 6158, LIMOS, Saint-Etienne, France. 2. SAMOVAR, Télécom SudParis, Institut Polytechnique de Paris, 91120 Palaiseau, France DOI:   10.52338/tjoad.2025.4759 Abstract: This article presents an experimental study of a location-based system designed to enhance the safety of residents’ ambulation within a nursing home. The primary objective is to assess the system’s impact on resident support, its acceptability, and its potential to improve the well-being of teams and families. To achieve this, a multi-phase protocol combining technical and medical validation has been designed, including tailored training sessions for users. The approach also includes a comprehensive analysis of the outcomes, based on b...

Pancreatic Body And Tail Cancer With Multiple Liver Metastases Cured By Precision Immunochemotherapy: A Case Report Correspondence to Author:  Taizo Hoshino 1 , Kazutoshi Kaketani 2 ,Takao Itoi 3 Yuichi Nagakawa 4 , Tetsu Fukunaga 5 , Hajime Orita 5 , Tadashi Okabe 6 .  1. Premiere Clinic, Tokyo, Japan 2. Hanzoumon Ichou Clinic, Tokyo, Japan 3. Tokyo Medical University Department of Gastroenterology and Hepatology, Tokyo, Japan 4. Tokyo Medical University Gastrointestinal and Pediatric Surgery, Tokyo, Japan 5. Esophageal & Gastroenterological Surgery, Juntendo University, Tokyo, Japan 6. Okabe Clinic, Tokyo, Japan DOI:   10.52338/taoim.2025.4861 Abstract: A 63 years-old female patient was found elevated CA19-9 levels during treatment for diabetes mellitus and further examinations led to a diagnosis of pancreatic body and tail cancer with multiple liver metastases. We performed whole-exome sequencing using a biopsy specimen and identified 70 somatic mutations, a part o...

  Retinoic Embryopathy: A Case Report of Mri Brain Findings. Correspondence to Author:  Abdulkhaliq Alhifzi, Ali Alhaidey, Suhayb Aldhilan, Abdullah Alhenaki, Faisal Alzahrani.  Abdulkhaliq Alhifzi, Radiology Department, Prince Sultan Military Medical City, Riyadh, Al-Riyadh Province Saudi Arabia, Email: hifzi1991@gmail.com. DOI:   10.52338/Appr.2025.4844 Abstract: Retinoic acid embryopathy is a rare but severe condition caused by prenatal exposure to isotretinoin, a potent teratogenic medication. This report describes a neonate who presented with distinct dysmorphic features and significant central nervous system abnormalities identified through magnetic resonance imaging (MRI). Key findings included near-complete absence of the cerebellar vermis, severe cerebellar dysplasia, microcephaly, and thinning of the corpus callosum. This case underscores the profound consequences of isotretinoin exposure during pregnancy and highlights the critical importance of stringent ...

Risk Factors For The Development Of Ureteric Stricture Post Ureteroscopic Lithotripsy: A Retrospective Analysis From A Tertiary Care Centre Correspondence to Author:  Aditya Mundada 1 , Rohan Nath 1 , Sasanka Kumar Barua 2 ,Puskal Kumar Bagchi 2 , Mandeep Phukan 3 ,Debanga Sarma 3 ,Nabajeet Das 4 .  1. Senior Resident, Department of Urology and Renal Transplant, Gauhati Medical College, Guwahati, Assam-781032. 2. Professor, Department of Urology and Renal Transplant, Gauhati Medical College, Guwahati, Assam-781032. 3. Associate Professor, Department of Urology and Renal Transplant, Gauhati Medical College, Guwahati, Assam-781032. 4. Assistant Professor, Department of Urology and Renal Transplant, Gauhati Medical College, Guwahati, Assam-781032. DOI:   10.52338/aou.2025.4840 Abstract: Background:  Urolithiasis is a globally prevalent disease with an increasing worldwide prevalence of 4 to 5%. A ureteral stricture is a common and serious complication of ureteroscopic l...

  A 10-Year Comparative Study Of Prevalence And Pattern Of Substance Abuse Among Patients In A Drug Treatment Center Correspondence to Author:  Delashik Dapap.  Delashik Dapap, Behind polo field, Jos, Nigeria. Email: ddapap@gmail.com DOI:   10.52338/jotr.2025.4687 Abstract: The abuse of drugs and substance is a global phenomenon. So much efforts has been made in many parts of the world to reduce the menace, but it seems such efforts are not yielding much fruits; but rather on the increase with attendant physical and mental health consequences. Over the last decade, drug addiction patterns have evolved, influenced by a variety of factors, including the availability of new substances, socio-economic pressures, and changes in public health approaches to treatment. According to world health organization (WHO), Substance abuse is consistently or sporadic drug use is inconsistent with or unrelated to acceptable medical practice.1 It is seen that drug abuse and drug depende...