Annals of Physical Medicine & Rehabilitation

 Retinoic Embryopathy: A Case Report of Mri Brain Findings.

Correspondence to Author: Abdulkhaliq Alhifzi, Ali Alhaidey, Suhayb Aldhilan, Abdullah Alhenaki, Faisal Alzahrani. 

Abdulkhaliq Alhifzi, Radiology Department, Prince Sultan Military Medical City, Riyadh, Al-Riyadh Province Saudi Arabia, Email: hifzi1991@gmail.com.

DOI: 10.52338/Appr.2025.4844

Abstract:

Retinoic acid embryopathy is a rare but severe condition caused by prenatal exposure to isotretinoin, a potent teratogenic medication. This report describes a neonate who presented with distinct dysmorphic features and significant central nervous system abnormalities identified through magnetic resonance imaging (MRI). Key findings included near-complete absence of the cerebellar vermis, severe cerebellar dysplasia, microcephaly, and thinning of the corpus callosum. This case underscores the profound consequences of isotretinoin exposure during pregnancy and highlights the critical importance of stringent preventive measures, including education, effective contraception, and regular pregnancy monitoring.

Keywords: Retinoic acid embryopathy, retinoic acid, isotretinoin, pregnancy.

Citation:

Abdulkhaliq Alhifzi, Retinoic Embryopathy: A Case Report of Mri Brain Findings. Annals of Physical Medicine & Rehabilitation 2025.

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