Annals of Dermatological Science

 Recent Advances in Collagen Biostimulators for Facial Rejuvenation: A Systematic Review in Aesthetic Dermatology.

DOI: 10.52338/aods.2025.4831

Abstract:

Introduction: Skin aging leads to loss of collagen, elasticity and facial volume, motivating the search for minimally invasive aesthetic procedures. Among the available strategies, collagen biostimulators have stood out as effective therapies for facial rejuvenation, promoting progressive dermal regeneration.
Objective: This systematic review aimed to analyze recent advances in the use of collagen biostimulators for facial rejuvenation in the practice of aesthetic dermatology.
Methodology: PubMed, Scopus, Web of Science and Embase were searched, including articles published between January 2019 and April 2025. Clinical studies, systematic reviews and meta-analyses that addressed the efficacy, safety and innovations in collagen biostimulators were included.
Results: 42 studies evaluating the use of poly-L-lactic acid (PLLA), calcium hydroxyapatite (CaHA) and polycaprolactone (PCL) in facial rejuvenation were selected. PLLA demonstrated efficacy in progressive dermal remodelling, CaHA provided immediate volumization and subsequent biostimulation, while PCL exhibited superior durability of clinical effects. All biostimulators showed favorable safety profiles, with a high patient satisfaction rate.
Conclusion: Collagen biostimulators have established themselves as essential elements in minimally invasive facial rejuvenation, offering natural and long-lasting results. Personalization of treatments and technical mastery are essential to optimize efficacy and minimize complications. Future research should focus on multicenter, long-term clinical trials to strengthen the available evidence.

Keywords: Collagen biostimulators; Facial rejuvenation; Aesthetic dermatology; Poly-L-lactic acid; Calcium hydroxyapatite; Polycaprolactone.

Citation:

Thiago Augusto Rochetti Bezerra, Recent Advances in Collagen Biostimulators for Facial Rejuvenation: A Systematic Review in Aesthetic Dermatology. Annals of Dermatological Science 2025.

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